Search party.

Where'd River go?!
She was in seclusion in the cuddle cube.  She was not happy with having to get a vet visit, eye drops, and a force-feeding (all courtesy of little human).  Poor little munchkin somehow managed to accidentally give herself an ouchie on her eyelid.

Where'd he go?!

River was very concerned when she noticed the big human's slippers with no big human in them (he had stepped outside while she wasn't looking).
She spent the next few minutes frantically searching for him.  She was a happy little camper when her favorite human reappeared if the nuzzling and chinning of his jeans and feet were anything to go by.